Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function, Identification of cytotoxic, glutathione reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion ScienceDirect Glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells ScienceDirect Intravenous Glutathione Therapy Dr. Ali, MD Health and Wellness Center Dr. Ali's Health and Wellness Center Holistic & Functional Medicine in Lake Forest & San Clemente