Full article: Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram