In patients with liver disease, acetaminophen metabolism is altered: the half life may be prolonged, and glutathione stores may be reduced, Therefore, acetaminophen can be used safely at reduced doses Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury Vliegenthart 2017 Clinical Pharmacology & Therapeutics Wiley Online Library PDF) Erratum to: The effects of acute acetaminophen toxicity on hepatic mRNA expression of SOD, CAT, GSH Px, and levels of peroxynitrite, nitric oxide, reduced glutathione, and malondialdehyde in rabbit Our Science Nacuity Pharmaceuticals
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acetaminophen reduces glutathione Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome