What is glutathione? Know as the most important antioxidant in the body, glutathione is an essential antioxidant manufactured in all cells, but primarily in the liver. It is essential because it Glutathione prevents high glucose induced pancreatic fibrosis by suppressing pancreatic stellate cell activation via the ROS TGF SMAD pathway Cell Death & Disease Glutathione deficiency induces epigenetic alterations of vitamin D metabolism genes in the livers of high fat diet fed obese mice Scientific Reports Role of glutathione peroxidase 1 in glucose and lipid metabolism related diseases ScienceDirect