Role of the glutathione pathway and ABC transporter family in drug elimination and defense from ROS mediated oxidative stress PDF] Interactions between biosynthesis, compartmentation and transport in the control of glutathione homeostasis and signalling. Semantic Scholar Glutathione is one of the most important molecules in detoxification. It drives Phase II conjugation and helps neutralize oxidative stress at the cellular level. But detoxification does not end with transformation. It Targeting Glutathione Metabolism: Partner in Crime in Anticancer Therapy