Insights into the Multifaceted Roles of Thioredoxin 1 System: Exploring Knockout Murine Models Functional plasticity of a peroxidase allows evolution of diverse disulfide reducing pathways PNAS Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox active selenolthiol selenenylsulfide formed from the conserved cysteine selenocysteine sequence PNAS Frontiers Assigning function to active site residues of Schistosoma mansoni thioredoxin glutathione reductase from analysis of transient state reductive half reactions with variant forms of the enzyme