Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Frontiers Potential adverse actions of prenatal exposure of acetaminophen to offspring Nini Munoz , PhD. Since the administration claimed Tylenol as a cause of autism, we've seen a number of alternative and 'integrative' practitioners talking Instagram Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.