Read this paper describing a large case series of patients with mast cell activation syndrome (MCAS) and comorbidities, whose MCAS associated symptoms improved significantly on GLP1 agonists. To summarize: 47 What if the real driver of your inflammation and bizarre symptoms isn't on your doctor's radar at all? Not autoimmune. Not just stress. Not in your head. I'm talking about mast cellsthey're An essential role for mast cells as modulators of neutrophils influx in collagen induced arthritis in the mouse Laboratory Investigation Mast Cell Activation Syndrome and the Triad of MCAS, POTS, and Hypermobile EDS : r IBSResearch