Oral vs. Topical Glutathione by Gluvit S: What Works Better for Skin B Oral glutathione has been everyone on my timeline but does it actually work?! Looking at the data, it's very modest to be honest. I'd recommend sticking to what we know works fo Melasma (Chloasma) Treatment Lack of efficacy of oral N acetylcysteine in the treatment of facial melasma in women: a randomized, double blind, placebo controlled clinical trial Anais Brasileiros de Dermatologia