Glutathione deficiency can lead to a variety of signs and symptoms that affect your overall health. Here are some common signs to look out for: 1. **Increased Dark Spots** Glutathione Understanding Glutathione Deficiency Invigor Medical During the prodromal phase of acute radiation sickness, which mechanism causes the symptoms: acute inflammation, direct caustic injury, glutathione depletion, or vascular compromise? Happy Week 6! Check out the graphic to learn more about Glutathione Synthetase Deficiency.