Jitteriness and anxietyafter taking a methyl donor ** Generally, only the people with the slow COMT variants who seem to be "Sensitive to Methyl Donors". It is really the buildup of SAH Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Glutathione and MTHFR Methyl Life Supplements Low Levels of the Antioxidant Glutathione Linked to Low Mood Psychology Today