What Peptides Are Legal in the U.S.? Understanding FDA Approval, Compounding, and the Legal Gray Areas FDA considers adding a dozen peptides to its bulk drug compounding list RAPS BPC 157 has a decades long safety record with zero deaths or hospitalizations. Yet, it's unapproved because the FDA process is too expensive and the business model doesn't allow for profit. Approved drugs with FDA Peptide Reclassification 2026: What Researchers Want