Insulin like growth factor 1 stimulates retinal cell proliferation via activation of multiple signaling pathways ScienceDirect IGF1 LR3 Peptide Anderson Longevity Clinic Frontiers Adverse event reporting of the IGF 1R monoclonal antibody teprotumumab: a real world study based on the US food and drug administration adverse event reporting system Local application of engineered insulin like growth factor I mRNA demonstrates regenerative therapeutic potential in vivo ScienceDirect