Full article: The acetaminophen metabolite N acetyl p benzoquinone imine ( NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5 oxoprolinuric acidosis? Immune mechanisms in acetaminophen induced acute liver failure Paracetamol toxicity Deranged Physiology 3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins.
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napqi and glutathione What Are the Potential Sites of Protein Arylation by N-Acetyl-p-benzoquinone Imine (NAPQI)?