Ive been saying this for years L carnitine isnt just some gym supplement, it actually makes a lot of sense for PCOS., For many women with PCOS, poor insulin sensitivity is a major issue that Adipocyte expressed SIRT3 manipulates carnitine pool to orchestrate metabolic reprogramming and polarization of macrophages Cell Death & Disease Metabolites as regulators of insulin sensitivity and metabolism Nature Reviews Molecular Cell Biology The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient Induced Lysine Acetylation of Mitochondrial Proteins ScienceDirect