Glutathione: Benefits and Supplements Does taking glutathione actually work?, Many people take glutathione supplements hoping for brighter, healthier skin., But heres the truth , Once glutathione is swallowed, it enters the stomach Skin safety should always come first. The Philippine Dermatological Society reminds the public that intravenous glutathione must not be used for skin whitening. It has weak evidence of effectiveness and carries FDA highlights concerns with using dietary ingredient glutathione to compound sterile injectables FDA