Tylenol uses up the liver's stores of GLUTATHIONE. Glutathione is the body's most important ANTIOXIDANT. The History of Acetaminophen Office for Science and Society McGill University Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Better alternatives for pain relief than Tylenol NSAIDs Turnpaugh Health & Wellness