GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Biochemistry Metabolism of acetaminophen (paracetamol) . Acetaminophen is widely used as a painkiller. Taken in the usual therapeutic doses, it is Instagram Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism