Does Acetaminophen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine In patients with liver disease, acetaminophen metabolism is altered: the half life may be prolonged, and glutathione stores may be reduced, Therefore, acetaminophen can be used safely at reduced doses