Leucovorin (Folinic Acid) The Rescue Drug! Pearl:Leucovorin (Folinic Acid) is Methotrexate's antidote. It is the reduced form of folate that can bypass the enzyme dihydrofolate reductase (which Methotrexate inhibits). Application: It Therapeutic Effects of Two Different Molecular Weights of Orally Administered Hyaluronan, Both as Monotherapy and in Combination with Methotrexate in a Rat Model of Arthritis Mitochondrial glutathione redox cycle and interaction with other antioxidant MedLink Neurology Frontiers Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress
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glutathione and methotrexate Glucarpi-CAP: A Retrospective Case Series of 1000-Unit Glucarpidase Dosing for Methotrexate Rescue