Paracetamol (acetaminophen) toxicity occurs when the liver is overwhelmed by a toxic metabolite called N acetyl p benzoquinone imine (NAPQI), which is normally detoxified by glutathione. In overdose, glutathione is depleted, and NAPQI accumulates, leading Acute acetaminophen paracetamol toxicity Maternal Biomarkers of Acetaminophen Use and Offspring Attention Deficit Hyperactivity Disorder Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums