Frontiers Acetaminophen induced liver injury: Molecular mechanism and treatments from natural products How can I minimize liver damage while taking Tylenol (acetaminophen) in relation to glutathione levels? Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Sex differences in glutathione metabolism and acetaminophen toxicity