Homocysteine May Decrease Glucose Uptake and Alter the Akt GSK3 GLUT1 Signaling Pathway in Hippocampal Slices: Neuroprotective Effects of Rivastigmine and Ibuprofen Molecular Neurobiology Springer Nature Link Ibuprofen administration attenuates serum TNF levels, hepatic glutathione depletion, hepatic apoptosis and mouse mortality after Fas stimulation ScienceDirect The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.