Explain how Inactivity or absence of Glucose 6 phosphate dehydrogenase ; a rate limiting enzyme in the Pentose phosphate pathway could lead to oxidative stress.* a. Oxidative Phase of Pentose phosphate pathway; b. Role of NADPH and Download Scientific Diagram Pentose Phosphate Pathway made simple. This pathway has two major jobs: Generate NADPH Produce ribose 5 phosphate NADPH protects cells from oxidative stress and supports fatty acid, cholesterol, steroid, nitric oxide, and respiratory burst Glucose 6 P DehydrogenaseAn Antioxidant Enzyme with Regulatory Functions in Skeletal Muscle during Exercise