Missouri warns of nitazene threat detected in schools statewide It's a name you've probably never heard: nitazenes. These synthetic opioids are being found in counterfeit pills, powders and vapes. Nitazenes are 5 to 10 times more potent than fentanyl. Even a What Are Nitazenes? A Deep Dive into These Potent Synthetic Opioids Not every pill is medicine and not every vape is nicotine. You don't always know what's inside. Some may contain synthetic opioids like Nitazenes or Fentanyl.