Can You Vape In Hotels Do Smoke Detectors Detect Vape? A Guide About Smoke Detectors Are Set Off By Vapes Smoke Pencil Air Leak Detection Will Vaping Set Off Hotel Smoke Alarms? Do Hotels Have Vape Detectors? Nexlar Security Your guests aren't the only ones checking in. So are their vape pens. With over 13 million regular vapers in the U.S. alone, unauthorized vaping is a major operational risk for hotels.